Prevention of Contrast-induced Nephropathy in Patients With Acute Myocardial Infarction
Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
OBJECTIVE: To evaluate the efficacy of prevention of contrast induced nephropathy in patients
with ST segment elevation myocardial infarction treated with primary percutaneous coronary
intervention.
DESIGN: Prospective study. SETTING: Three-center study Acute kidney injury was defined as a
rise in creatinine >25% from baseline Serum creatinine will be measured at baseline and each
day for the following 3 days and at 30 days.
Patients will be randomised to:
1. Standard treatment
2. Standard treatment + acetylcystein for 2 days
3. Standard treatment + Sodium bicarbonate 500 ml / followed by 100 ml/h for 5 hours
4. Standard treatment + acetylcystein for 2 days + Sodium bicarbonate 500 ml / followed by
100 ml/h for 5 hours