Prevention of Chronic Lung Disease (CLD) in Preterm Infants
Status:
Unknown status
Trial end date:
2013-04-01
Target enrollment:
Participant gender:
Summary
Pulmonary inflammation plays an important role in the early development of CLD. Postnatal
glucocorticoids have been shown effective in the prevention or treatment of CLD with various
success. However, systemic glucocorticoid therapy often associated with various short term
and long term complications. Therefore, modification of the therapeutic regimen is needed.
Inhaled steroid, including inhaled budesonide,have been tried but the results are essentially
unsuccessful, most likely due to small airways that the inhaled steroid reaching to the
peripheral lungs are limited and unpredictable. Direct instillation of budesonide into the
airway has also shown to be ineffective, possibly due to poor distribution of steroid in the
lungs.
The investigators hypothesize that intratracheal instillation of budesonide, a strong
tropical steroid, using surfactant as vehicle would facilitate the delivery of budesonide to
the lung periphery and would inhibit lung inflammation and improve the pulmonary outcome. The
result of our pilot study (Pediatrics, 2008) indicated this high possibility.
Phase:
Phase 4
Details
Lead Sponsor:
China Medical University, China
Collaborators:
Cathay General Hospital Chang Gung Memorial Hospital National Taiwan University Hospital Taipei Medical University Hospital