Prevention of Chemotherapy-induced Cardiotoxicity in High-risk Patients
Status:
Completed
Trial end date:
2011-11-01
Target enrollment:
Participant gender:
Summary
In cancer patients, the increase of troponin I soon after chemotherapy is a strong predictor
of left ventricular dysfunction and poor cardiologic outcome. This information provides a
rationale for the development of prophylactic strategies directed against
chemotherapy-induced cardiotoxicity (CTIC). Activation of the renin-angiotensin system has
been proved to be involved in the development and progression of cardiac dysfunction in
several clinical settings, and has been suggested to have a role in the occurrence of CTIC.
We investigated the role of treatment with ACE-inhibitors in the prevention of CTIC in
high-risk cancer patients.