Prevention of Catheter-Associated Infection With the Skin Disinfectant Octenidine Dihydrochloride
Status:
Completed
Trial end date:
2005-04-01
Target enrollment:
Participant gender:
Summary
Health-care-acquired infections are of tremendous importance for patients, especially
catheter-associated infections. More than 40% of all bloodstream infections are associated
with central venous catheters (CVC; catheters which are inserted into a large vein near the
heart). Of all patients that acquire such an infection 1% to 5% die as a result from it. The
insertion site is the main source of contamination and infection. In general, bacteria of the
skin are the cause of infection, especially in short-term CVCs (10-14 days). Therefore it is
necessary to efficiently disinfect the skin for the preparation and care of CVC insertion
sites. Several substances are used for disinfection. Alcohol-based disinfectants are mainly
used in Central Europe, other preparations contain povidine-iodine or chlorhexidine.
Alcoholic disinfectants have a rapid initial effect, chlorhexidine shows an additional
remanent (longer lasting) effect. A further substance, octenidine dihydrochloride, also
demonstrated a remanent effect in a pilot study with neurosurgical patients. The purpose of
our study is to compare an alcohol-based disinfectant containing octenidine dihydrochloride
with a pure alcoholic disinfectant regarding efficacy and tolerability in patients receiving
a CVC for a minimum of 5 days.