Overview

Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery

Status:
Completed

Trial end date:
2008-02-01

Target enrollment:
0

Participant gender:
All

Summary

The investigators hypothesize that the medication amiodarone decreases the incidence of atrial fibrillation (AF) following non-cardiac open-chest surgery. Their specific aims are to: - Determine the effectiveness of amiodarone for the prevention of AF following non-cardiac open-chest surgery; - Determine the influence of the prevention of AF following non-cardiac thoracic surgery on post-surgical duration of stay in the Intensive Care Unit (ICU); post-surgical duration of stay in a hospital unit that employs cardiac monitoring; and duration of post-surgical hospital stay; and - Determine the safety of amiodarone for the prevention of AF following non-cardiac open-chest surgery.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Indiana University

Collaborator:

Purdue University

Treatments:

Amiodarone

Criteria

Inclusion Criteria:

- Males or females over the age of 40

- Scheduled to undergo pneumonectomy or lobectomy

Exclusion Criteria:

- History (hx) of atrial fibrillation

- Prior severe side effects from amiodarone

- Elevated liver enzymes >3 times the upper limit of normal (UNL)

- QTc interval > 450 ms

- Receiving class Ia or class III antiarrhythmics