Prevention of Arrhythmia Device Infection Trial (PADIT)

• Status: Completed
• Trial end date: 2017-09-08
• Target enrollment: 0
• Participant gender: All

Summary

The goal of the study is to compare whether a center-wide policy of incremental antibiotic therapy will reduce CIED infection rate compared to a policy of conventional antibiotic prophylaxis in high-risk patients undergoing arrhythmia device procedures. All antibiotics used are approved for use and readily available.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Population Health Research Institute
• Collaborator: Canadian Institutes of Health Research (CIHR)
• Treatments: Anti-Bacterial Agents; Bacitracin; Cefazolin; Cephalexin; Vancomycin

Criteria

Inclusion Criteria:

1. Age >= 18 years

2. Received one of the following procedures:

1. A second or subsequent procedure on the arrhythmia device pocket:

ICD, pacemaker, CRT-P, CRT-D generator and/or lead replacement

2. Pocket or lead revision

3. System upgrade (insertion or attempted insertion of leads)

4. New cardiac resynchronization therapy device implant (pacemaker or ICD)

3. Patient is not known to have device infection at the time of the surgery