Prevention of Acute Voiding Difficulty After Radical Proctectomy

• Status: Completed
• Trial end date: 2010-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Various adrenergic blockers are used for acute voiding difficulty after proctectomy. Recently, a selective alpha5-adrenergic blocker, Tamsulosin has been reported to have benefit in reducing urinary symptom score and in reducing the rate of intermittent self-catheterization for patients with rectal cancer after radical proctectomy.

This study is to evaluate the efficacy of pharmacologic prevention to ameliorate the incidence of postoperative urinary dysfunction.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Tamsulosin

Criteria

Inclusion Criteria:

• Patients between 20-80 years old in general good health

• Patient willing to participate in the study

• Patient who understands and accepts to sign the informed consent form

• Patient who received proctectomy for rectal cancer located 15 cm or less of the anal verge

Exclusion Criteria:

• Documented problem of preoperative urinary dysfunction

• Any post-surgery change in patient condition which requires insertion of urinary catheter after surgery

• Past history of recurrent urinary tract infection or malignancy of urinary system organs

• Past history of surgery for urinary system organs

• Current administration of Finasteride or Dutasteride

• Liver dysfunction (SGOT or SGPT 100 IU/L or more)

• Kidney dysfunction (serum Creatinine 3mg/dl or more)