Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract
Status:
Unknown status
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
The colonization of potential pathogenic bacteria in lower respiratory tract is thought to be
accountable for acute exacerbation in subjects with moderate to severe COPD. However, there
is no accepted therapy for patients with COPD to remove the colonized bacteria in lower
respiratory tract. Therefore, we plan to perform a multi-center, randomized, controlled trial
to study the efficacy and safety of oral probiotics, aerosol inhaled amikacin or combined
vaccination to decolonize bacteria in lower respiratory tract and prevent acute exacerbation
of COPD.
Phase:
Early Phase 1
Details
Lead Sponsor:
Shanghai Zhongshan Hospital
Collaborators:
Ruijin Hospital The First Affiliated Hospital of Guangzhou Medical University