Prevention for Mother-to-infant Transmission of HBV
Status:
Completed
Trial end date:
2014-08-01
Target enrollment:
Participant gender:
Summary
In this study, HBV-infected pregnant women were divided into two groups, those who received
and those who did not receive hepatitis B immunoglobulin (HBIG) during pregnancy. In the
mothers, the changes in HBV serum markers (hepatitis B surface antigen (HBsAg), hepatitis B
surface antibody (HBsAb), HBeAg, hepatitis B core antibody (HBcAb)), and the DNA load were
investigated. Immunohistochemical staining with custom-made antibodies against HBIG revealed
both the level and distribution of HBIG in placentas. The protective mechanism of HBIG
administrated during pregnancy was explored.
Phase:
N/A
Details
Lead Sponsor:
Health Science Center of Xi'an Jiaotong University Health Science Center of Xi’an Jiaotong University