Preventing Malaria During Pregnancy in Epidemic-prone Areas.
Status:
Completed
Trial end date:
2007-01-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare the efficacy and cost-effectiveness of three
alternative strategies for the prevention of malaria during pregnancy in an epidemic-prone
area of low transmission in the East African Highlands.
The strategies being compared are:
- intermittent preventive treatment with sulfadoxine-pyrimethamine (IPT-SP)
- an insecticide treated net (ITN), and
- intermittent preventive treatment with SP plus an ITN
In addition to the main individually-randomised trial, outcome data was subsequently also
gathered on pregnant women whose houses where sprayed with indoor residual insecticides (IRS)
as part of a non-randomised district-wide control programme to compare the impact of IRS with
the three intervention arms.
Phase:
Phase 3
Details
Lead Sponsor:
Gates Malaria Partnership London School of Hygiene and Tropical Medicine
Collaborator:
Ministry of Health, Uganda
Treatments:
Fanasil, pyrimethamine drug combination Pyrimethamine Sulfadoxine