Preventing Injured Knees From osteoArthritis: Severity Outcomes
Status:
Recruiting
Trial end date:
2029-12-01
Target enrollment:
Participant gender:
Summary
This study is being done to find out if metformin is effective at reducing pain by delaying
the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL)
reconstruction. This research study will compare metformin to placebo. The placebo tablet
looks exactly like metformin, but contains no metformin. Placebos are used in research
studies to see if the results are due to the study drug or due to other reasons.
Metformin is approved by the U.S. Food and Drug Administration (FDA) to treat type II
diabetes. Notably, it also has anti-inflammatory effects, suggesting it could benefit people
who have an ACL injury and are undergoing ACL reconstruction.