Preventing Brain Injury in Infants With Congenital Heart Disease
Status:
Completed
Trial end date:
2017-07-28
Target enrollment:
Participant gender:
Summary
Newborn babies with congenital heart disease often require surgery in the first month of
life. The risks of brain damage from congenital heart disease and from the various corrective
surgeries are high because of poor levels of oxygen reaching the brain. Topiramate is an
anti-convulsant medication that protects brain cells from damage due to low amounts of oxygen
in animal studies. The investigators hypothesize that giving topiramate to babies with
congenital heart disease before and after surgery will decrease the amount of brain damage
caused by the heart disease and/or the surgery to correct the heart disease.