Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy

• Status: Unknown status
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether sodium bicarbonate is effective in reducing kidney injury that may occur during cardiac surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: McGill University Health Center; McGill University Health Centre/Research Institute of the McGill University Health Centre

Criteria

Inclusion criteria:

• age greater than or equal to 18 years

• elective or urgent CABG +/- valve surgery, or elective or urgent isolated valve surgery

• exposure to cardiopulmonary bypass

• stable kidney disease: less than 25% change in serum creatinine during 3 months before surgery

• Estimated glomerular filtration rate, by Modification of Diet in Renal Disease (MDRD) equation, less than or equal to 60 ml/min/1.73m2

Exclusion criteria:

• emergency CABG, cardiac transplantation, or insertion of VAD

• planned off-pump surgery

• N-acetylcysteine given in last 72 hours prior to operation

• radiocontrast given in last 48 hours prior to operation

• acute renal failure (greater than 25% increase in serum creatinine from preadmission baseline)

• glomerular filtration rate less than 15 ml/min or chronic dialysis

• prior renal transplantation

• enrollment in another research study, with the exception of MUHC study SDR-05-033

• LV ejection fraction less than or equal to 20%