Preservative-free Topical Anesthetics for Post-PRK Pain

• Status: Completed
• Trial end date: 2023-01-30
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this interventional comparative study is to assess the efficacy and safety of a novel regimen of preservative-free topical anesthetics for controlling early postoperative pain following single-step transepithelial PRK surgery.

The main questions it aims to answer are:

• Question 1: Are topical anesthetics effective in reducing post-PRK pain?

• Question 2: Do topical anesthetics inversely affect the epithelial healing duration? Participants will undergo a bilateral single-step transepithelial PRK surgery to correct their refractive errors and will receive a standard post-PRK treatment regimen for both eyes. Additionally, one eye will be offered a preservative-free topical anesthetic as an experimental group and the other eye will be offered a preservative-free artificial tear as a control placebo group.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assiut University
• Treatments: Benoxinate; Hyaluronic Acid

Criteria

Inclusion Criteria:

Patients who are candidate for PRK surgery with

1. Myopia up to - 6 diopters or myopic astigmatism up to - 4 diopters.

2. Corneal thinnest pachymetry of 500 µm

3. Residual stromal bed more than 350 µm after epithelial ablation.

Exclusion Criteria:

Patients with

1. Corneal scars or dry eye disease,

2. Past ocular surgery,

3. History of contact lens wear,

4. Systemic diseases such as diabetes mellitus and autoimmune diseases,

5. History of oral analgesics abuse.