Preparing and Timing of the Endometrium in Modified Natural Cycle Frozen-thawed Embryo Transfers
Status:
Recruiting
Trial end date:
2023-01-01
Target enrollment:
Participant gender:
Summary
The increasing use of FET emphasizes the importance of preparing and timing the endometrium
in FET cycles, however there is no consensus on luteal phase progesterone supplementation in
mNC-FET and the optimal day of blastocyst warming and transfer. The aim of this multicenter
RCT is to assess the effect of progesterone supplementation in hCG-triggered mNC-FET and the
effect of embryo thawing and transfer at hCG+6 or hCG+7 days, respectively. In total 604
patients will be included with n=151 in each of the four study arms. The primary outcome is
live birth rate per transfer (LBR) and the goal is to show a 10% increase in LBR after
progesterone supplementation and to assess whether blastocyst warming+transfer 6 days after
hCG trigger is superior to 7 days after hCG trigger in mNC-FET.
Phase:
Phase 4
Details
Lead Sponsor:
Anja Bisgaard Pinborg
Collaborators:
Aalborg University Hospital Copenhagen University Hospital at Herlev Copenhagen University Hospital, Hvidovre Hillerod Hospital, Denmark I. Fertility Clinic, Hvidovre Hospital, Copenhagen University Hospital II. Kvindeafdelingen, Horsens og Institut for Klinisk Medicin, Århus Universitet III. Fertility Clinic, Herlev Hospital, Copenhagen University Hospital IV. Fertilitetsenheden og Center for Præimplantationsdiagnostik, Ålborg Universitetshospital Regionshospitalet Horsens Regionshospitalet Viborg, Skive Zealand University Hospital