Colonoscopy is a routinely performed examination of children and adolescents in the
diagnostic process of inflammatory bowel disease (IBD). It is necessary that the bowel is
clean so the colonoscopy can be optimally performed. The cleansing of the bowel by means of
laxatives prior to the examination is, however, considered difficult by many children.
Getting smaller children to cooperate and to drink a substantial volume of laxative fluid
prior to the examination can be particularly difficult. There are several possible cleansing
procedures and combinations of procedures for the cleansing of the colon, for example by
means of polyethylene glycol and sodium picosulphate, which are the two most commonly used
methods. Cleansing by means of polyethylene glycol can, due to the necessary intake of a
substantial quantity of fluid, be particularly frustrating for patients. Often the only way
to carry out the preparation is with the insertion of a nasogastric tube, which can cause
discomfort for some children. Cleansing the colon by means of sodium picosulphate, which
involves an intake of a small quantity of fluid, has been suggested to be a good sufficient
method resulting with a satisfactory result in terms of bowel cleanliness. However, studies
have so far encompassed only a smaller number of children and further studies are needed to
confirm that there is no difference between the two methods in terms of resultant bowel
cleanliness.
The purpose of this randomized controlled study is to compare preparation by means of
polyethylene glycol and preparation with sodium picosulphate prior to colonoscopy in
children.
One hundred children scheduled for colonoscopy in southern Sweden will be randomized into
either patient group 1 (for preparation with polyethylene glycol) or patient group 2 (for
preparation with sodium picosulphate). For the random sampling, data-driven selection will be
implemented. A CONSORT Flowchart (2012) will be encompassed by the study. To assess the
cleanliness of the intestinal tract (and volume of fluid in the intestine), the Ottawa Scale
will be used (Rostom & Jolicoeur, 2009). All colonoscopy examinations will be performed by
the same paediatric gastroenterologist, to whom no information about which preparation method
was used by each child will be disclosed. Furthermore, the gastroenterologist will, meet with
the children first after the investigation has been completed. All information regarding the
investigation will be given to the patient by the admitting physician. During the colonoscopy
the gastroenterologist will evaluate the intestinal cleanliness and submit the reports in
sealed coded envelopes to the nurse in charge of the patient.