Overview

Preoperative and Postoperative Imatinib Mesylate Study in Patients With c-Kit Positive GIST

Status:
Completed
Trial end date:
2011-07-01
Target enrollment:
0
Participant gender:
All
Summary
Primary objectives 1. To determine whether induction of apoptosis or inhibition of angiogenesis are involved in the antitumor activity of (Gleevec, Formerly STI-571) in patients with gastrointestinal stromal tumors (GIST) as assessed by Positron Emission Tomography (PET) scanning. 2. To determine whether dynamic computed tomography (CT), PET scan, molecular and histopathologic responses in GIST tumors from patients treated with Gleevec predict Disease-Free Survival (DFS) time. Secondary objectives 1. To determine the disease free survival of patients with resectable or partially resectable gastrointestinal stromal tumors treated with Gleevec preoperatively and continued for 2 years after resection of disease. 2. To assess the safety and tolerability of Gleevec given to patients with GI stromal tumors 3, 5, or 7 days preoperatively and continued postoperatively.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
M.D. Anderson Cancer Center
Collaborator:
Novartis
Treatments:
Imatinib Mesylate
Criteria
Inclusion Criteria:

1. Signed informed consent.

2. Patients must have a histologically proven diagnosis of primary, locally advanced
and/or metastatic GIST for which complete or partial resection is planned by a MDACC
sarcoma surgeon.

3. Patients must have immunohistochemical documentation of kit expression in the tumor
using the DAKO A4502 or other acceptable antibody.

4. Patients must have a least one lesion greater than 1 cm that can be accurately
measured in one dimension by plain radiograph, CT or magnetic resonance imaging (MRI).

5. Patients must have normal organ and marrow function (White blood count-WBC greater
than or equal to 3,000/ul, Absolute neutrophil count (ANC) greater than or equal to
1500/ul, platelets greater than or equal to 100,00/ul, total bilirubin less than or
equal to 1.5 * Upper Limits of Normal (ULN), aspartate aminotransferase (AST or SGOT)
or alanine aminotransferase (ALT or SGPT) less than or equal to 2.5 * ULN, serum
creatinine less than or equal to 1.5 * ULN).

6. Patients must have a serum glucose < 200 mg/dl prior to PET scan. Patients must be
able to lie flat and still for the PET scan.

7. Patients may not have any uncontrolled medical or psychiatric conditions that would
make the patient unable to tolerate therapy. Patients with uncontrolled medical
conditions or psychiatric conditions may have informed consent granted by a legal
guardian or surrogate decision maker.

8. Patients may not have any prior malignancy in the past 5 years other than non-melanoma
skin cancer, cervical cancer in situ, or any other malignancy that is not currently
clinically significant.

9. Zubrod performance status of 0 - 3.

10. May not have metastases outside of the peritoneal cavity.

11. If patients have any signs or symptoms of metastases, the appropriate workup should
occur prior to enrollment (eg, CT of the head for a patient with central nervous
system (CNS) symptoms).

12. Patients may not have had chemotherapy, radiotherapy, biological therapy or any
investigational drugs 3 weeks prior to the study.

13. Women should have a negative pregnancy test within 7 days of study opening.

14. Patients must agree to use an effective contraceptive method.

Exclusion Criteria:

1. Prior treatment using Gleevec.

2. Patients with Class III or Class IV New York Heart Association congestive heart
failure.

3. Pregnant or nursing women.

4. Patients taking therapeutic doses of Coumadin for anticoagulation. Coumadin may be
taken but dose should be less than or equal to 1 mg po per day. Patients MAY take a
low molecular weight heparin.