Overview

Preoperative Teriparatide Use on Insertional Torque of Pedicle Screws for Lumbar Fusion Surgery

Status:
Recruiting

Trial end date:
2022-06-30

Target enrollment:
0

Participant gender:
All

Summary

This project aims to investigate any difference of insertional torque strength for osteoporotic patients with preoperative 1-month teriparatide injections versus those without. The increased insertional torque of pedicle screws during surgery after only 1 month of teriparatide use has also been studied. However, the effect of teriparatide on vertebral body bone mineral density (BMD) prior to and after fusion surgery has not been studied. The effects on screw insertional torque has also not been studied via a randomized controlled trial method.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

The University of Hong Kong

Treatments:

Teriparatide

Criteria

Inclusion Criteria:

- Patients must be osteoporotic: baseline BMD assessed by DEXA scan must be considered
as osteoporotic (>2.5 SD from sex-matched young adult, or previous vertebral and/or
femoral fractures) and indicated for spinal fusion surgery

Exclusion Criteria:

- Paget disease of bone, high laboratory tests for serum alkaline phosphatase or
calcium, previous radiation treatment or fusion surgery to lumbar spine, bone tumors,
metabolic bone disease, and hypersensitivity to teriparatide