Preoperative Single-dose Steroid Application for the Treatment of Nausea and Vomiting After Thyroid Surgery

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The study is to compare the postoperative recovery, as determined by postoperative nausea and vomiting (PONV) after preoperative application of single-dose dexamethasone versus saline in patients undergoing partial or total thyroidectomy.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cantonal Hospital of St. Gallen
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Age > 18

• Planned partial or total thyroidectomy

Exclusion Criteria:

• History of adverse effects to dexamethasone or propyleneglycol or di-natrium-EDTA

• Patients with chronic pain

• Necessity for opioids-application in the postoperative course

• Not possible administration of a cervical block (0.5% bupivacaine at a dose of 20ml)

• Patients with Diabetes mellitus

• Pregnancy (test in young women)

• Glaucoma

• Patients who received antiemetic therapy within 48h before surgery

• Patients with acute pain requiring painkillers others than paracetamol or more than single dose NSAR treatment within 48h before surgery

• Use of psychotropic drugs

• Incompliant patients

• Preoperatively high suspicion of malignancy

• Re-operations