Preoperative Paravertebral Block in Cancer Surgery of the Lung

• Status: Recruiting
• Trial end date: 2022-05-31
• Target enrollment: 0
• Participant gender: All

Summary

The investigators aim to determine whether ultrasound-guided preemptive paravertebral blockade (PVB) local anaesthetic (pre-PVB LA), administered in addition to the post-operative PVB (post-PVB) local anaesthetic (LA) infusion, reduces acute postoperative pain, opioid requirement, chronic pain, and improves surgical recovery, in thoracoscopic surgery for lung cancer.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guy's and St Thomas' NHS Foundation Trust
• Treatments: Bupivacaine; Levobupivacaine

Criteria

Inclusion Criteria:

• Elective radical primary lung cancer VATS surgery for single lobectomy

• American Society of Anesthesiology (ASA) I-III

• Age ≥18

Exclusion Criteria:

• Planned open thoracotomy, wedge resection, bilobectomy, pneumonectomy, chest wall resection or total pleurectomy

• Local anaesthetic or opioid allergy

• Coagulation disorders

• Inability to comply with study questionnaire completion

• Pre-existing pain in chest area or pre-existing pain conditions

• Local infection/tumour at proposed PVB site

• Previous lung surgery

• Planned surgery within 3 months of the primary lung resection