Preoperative Misoprostol in Reducing Blood Loss in Total Abdominal Hysterectomy (TAH)

• Status: Completed
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

Total abdominal hysterectomy is known to be associated with operative blood loss, which can lead to patients' morbidity. Misoprostol, a prostaglandin, has been shown to be effective in reducing operative blood loss during myomectomy. It is the first study to investigate if preoperative misoprostol is effective in reducing operative blood loss during total abdominal hysterectomy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Hong Kong
• Treatments: Misoprostol; Pyridoxal; Pyridoxine; Vitamin B 6; Vitamin B Complex; Vitamins

Criteria

Inclusion Criteria:

• symptomatic women undergoing total abdominal hysterectomy for various benign gynaecological diseases in Queen Mary Hospital

Exclusion Criteria:

• any contraindication to misoprostol, including mitral stenosis, glaucoma, sickle cell anaemia, diastolic pressure over 100mmHg, severe asthma, or known allergy to prostaglandin;

• a known history of pelvic/ovarian endometriosis;

• a known history of or active medical disease;

• a known history of previous myomectomy;

• women who had pre-operative mifepristone or gonadotrophin releasing hormone analogues treatment;

• women with mental impairment or incompetent in giving consent.