Preoperative Methadone Single Dose Reduces Postoperative Morphine Consumption.

• Status: Completed
• Trial end date: 2018-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to evaluate the effect of intraoperative methadone on postoperative analgesic requirements, pain scores and patient satisfaction in comparison to standard intraoperative pain control with fentanyl.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kantonsspital Baden
• Treatments: Fentanyl; Methadone; Morphine

Criteria

Inclusion Criteria:

• informed consent

• Patients of both genders and up to age 75 and ASA classification III were enrolled, when undergoing moderately to severely painful surgery scheduled for ≥90 minutes in general anaesthesia.

• german speaking patients

Exclusion Criteria:

• patients including other studies

• pregnant

• breast feeding

• patients in methadone substitution therapy

• dependent drug user

• patients with BMI greater than 36kg/m2

• patients with chronic or acute renal failure with serum creatinine greater than 400µmol/L

• patients with liver insufficiency or failure

• alcoholics

• patients with acute heard attack