Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter

• Status: Not yet recruiting
• Trial end date: 2024-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess if preoperative treatment with Lugol's solution prior to thyroidectomy can reduce the surgical complications hypoparathyroidism and laryngeal nerve palsy

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jan Calissendorff
• Treatments: Lugol's solution; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Hyperthyroidism accepted for thyroidectomy due to toxic nodular goiter with free T4 <30 pmol/L or Graves' disease

• Signed informed consent

Exclusion Criteria:

• Unstable coronary artery disease

• Previous thyroid surgery

• Congestive heart failure

• Renal insufficiency

• Hepatic failure

• Current infection

• Treatment with steroids or anticoagulants

• Thyroid associated orbitopathy CAS > 2

• Diabetes mellitus type 1

• Active cancer

• Severe psychiatric illness

• Amiodarone treatment

• Pregnancy

• Breast feeding

• Women of child bearing potential not using contraceptive

• Inability to comprehend the meaning of the study

• Iodine hypersensitivity