Preoperative High-dose Dexamethasone and Emergency Laparotomy
Status:
Recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
The aim of this trial is to evaluate the effect of high-dose glucocorticoid on inflammatory
response and recovery after emergency laparotomy in participants with intestinal obstruction
and perforated viscus.
Primary outcome is the reduction of C-reactive protein on postoperative day 1. Secondary
outcomes are organ specific complications in the post anaesthesia phase, endothel and
inflammatory markers, fluid status, preload dependency, pain, lung function, nausea and
mobilization during the first 5 days after surgery, .
The investigators hypothesize, that a preoperative single high dose of glucocorticoid reduces
systemic inflammatory response after emergency laparotomy.