Preoperative Dexmedetomidine & EC50 of Propofol

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Dexmedetomidine is a useful anaesthetic adjuvant for general anaesthesia. In this prospective randomised study, we determined whether preoperative dexmedetomidine administration could reduce the half maximal effective concentration (EC50) of propofol for successful i-gelTM insertion without muscle relaxants.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• ASA physical status I-II patients who were 20-65 years old and scheduled for general anaesthesia for urologic surgery

Exclusion Criteria:

• Patients with an allergy to alpha-2 adrenergic agonists or propofol

• Patients who anticipated difficult airway (cervical spinal disease, Mallampati score of III or IV, a mouth opening of <2.5 cm, and/or body mass index of >30 kg m-2), unstable teeth

• Patients with bradycardia of <50 beats/min, heart block greater than first degree, severe cardiorespiratory dysfunction

• Patients with symptoms of upper respiratory infection