Preoperative Corticosteroids in Autoimmune Thyroid Disease

• Status: Not yet recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This study proposes to randomize patients about to undergo surgery for their autoimmune, inflammatory thyroid disease, and determine if a short course of corticosteroids decreases the inflammation of the gland and makes surgery less difficult.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Indiana University
• Treatments: Dexamethasone

Criteria

• Inclusion Criteria:

■ Graves' disease or Hashimoto's disease with positive thyroid autoantibodies (TgAb, TPO, TSI, and/or TRAb) undergoing total thyroidectomy for their disease.

• Exclusion Criteria:

• Pediatric patients < 18

• Prior treatment with RAI

• Prior neck surgeries

• Known diagnosis of thyroid cancer

• Diabetic patients on medications

• Patients on any immunosuppressive regimen (such as organ transplant patients or patients treated for other autoimmune conditions). This includes patients with recent history of steroid therapy.

• A history of adverse reactions to corticosteroids.

• Patients who are receiving a concomitant medication that interacts negatively with corticosteroids.