Preoperative Antibiotic Dosing for Total Knee Arthroplasty

• Status: Withdrawn
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: All

Summary

To directly compare acute infection rates in patients undergoing total knee replacement with intraosseous regional administration or systemic intravenous administration of prophylactic antibiotics.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cefazolin

Criteria

Inclusion Criteria:

•primary diagnoses of osteoarthritis

Exclusion Criteria:

• history of compartment syndrome

• allergy to an antibiotic in the study

• venous stasis

• peripheral vascular disease