Overview

Premedication to Mitigate Amivantamab Infusion Related Reactions

Status:
Not yet recruiting
Trial end date:
2024-06-30
Target enrollment:
Participant gender:
Summary
The purpose of the study is to separately assess the potential of dexamethasone, montelukast and methotrexate, administration, prior to amivantamab infusion given through a needle in the vein, to decrease the incidence and/or severity of infusion related reaction (IRR), when amivantamab is given in combination with Lazertinib (by mouth), to reduce first-dose IRRs.
Phase:
Phase 2
Details
Lead Sponsor:
Janssen Research & Development, LLC
Treatments:
Amivantamab-vmjw
Dexamethasone
Lazertinib
Methotrexate
Montelukast