Premedication and Haemodynamics After Spinal Anesthesia
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
Blood pressure drop following spinal anesthesia is connected with sympathetic/parasympathetic
activity which may be determinated by Heart Rate Variability (HRV) assessment. Sympathetic
predomination expressed as LF/HF ratio above 2.5 is strongly connected with deeper blood
pressure fall. As drugs given for premedication may have impact on HRV variables, the
investigators would like to determine if pharmacological premedication may modify hemodynamic
changes following spinal blockade. Two drugs will be compared - midazolam which is known to
lead to increase in LF/HF ratio and morphine - opioid which provokes opposite effect.