Premedication With Labetalol Versus Metoprolol for Controlled Hypotension During Endoscopic Nasal Surgeries
Status:
Recruiting
Trial end date:
2022-06-15
Target enrollment:
Participant gender:
Summary
Background: Mucosal bleeding is the most frequent complication with endoscopic nasal
surgeries, as it interferes with the optimal visualization of the intranasal anatomy, leading
to increased risk of complications, increased operation time, and increased blood loss. There
are several pharmacological techniques for the appropriate control of intraoperative
bleeding.
Objectives: To compare the safety and efficacy of oral labetalol versus oral metoprolol as a
premedication for controlled hypotensive anesthesia during endoscopic nasal surgeries.
Patients and Methods: This is a randomized, double-blind, phase four, comparative clinical
trial; carried out on 60 patients, who were candidates for endoscopic nasal surgeries under
general anesthesia at our hospital. Patients were randomly allocated into two equal groups;
group L, received oral labetalol, and group M, received oral metoprolol.