Overview

Preliminary Results for the Double-dose Adenovirus-mediated Adjuvant Therapy Improving Outcome of Liver Transplantation in Patients With Advanced Hepatocellular Carcinoma

Status:
Completed
Trial end date:
2013-08-01
Target enrollment:
0
Participant gender:
All
Summary
HCC patients with tumors >5 cm in diameter, regardless of involvement in the intrahepatic and extrahepatic portal branches participated in the study. Patients were randomized allocated in liver transplantation (LT) only group and LT plus ADV-TK therapy group. All patients received orthotopic liver transplantation; in the LT plus ADV-TK group, ADV-TK therapy was delivered to patients twice.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Huazhong University of Science and Technology
Collaborator:
Beijing YouAn Hospital
Treatments:
Ganciclovir
Ganciclovir triphosphate
Liver Extracts
Criteria
Inclusion Criteria:

- 18~70 years of age (Male and Female).

- Clinical diagnosis of advanced hepatocellular carcinoma who could accept liver
transplantation

- Patients who had unresectable HCC >5 cm and no metastasis in lungs and bones were
eligible to participate in this study. Tumor involvement in the intrahepatic and
extrahepatic portal branches was not considered to be an exclusion criterion.

- No prior chemotherapy, radiation therapy, targeted therapy or other kind of biological
treatment within 4 weeks.

- Provide written informed consent

Exclusion Criteria:

- Metastasis in lungs and bones

- Invasion in main vescular.

- Contraindications of liver transplantation

- Contraindications of operation of other organ system

- Hypersensitivity to adenovirus, GCV or similar drugs

- Accept clinical trials of other drugs

- Immunological deficit

- Active pregnancy

- Unable or unwilling to sign informed consents