Pregnenolone Trial for Depression in Bipolar Disorders or Recurrent Major Depressive Disorder With Substance Abuse
Status:
Completed
Trial end date:
2006-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this research is to determine if pregnenolone supplement is associated with a
reduction in substance use and craving in patients with recurrent major depressive disorder
or bipolar disorder and substance abuse/dependence. This research also wants to explore if
pregnenolone supplements are associated with improvement in psychiatric symptoms and memory,
which are often negatively affected in these patients. It is hypothesized that patients
receiving pregnenolone supplements would show greater improvements in mood symptoms and
memory, and crave substances less than the patients receiving placebo.