This study is being done to evaluate the effects of pregabalin, a drug approved for
anticonvulsive therapy and for neuropathic pain, on colonic and sensory functions in healthy
individuals.
The specific study hypotheses were as follows: 1) pregabalin increases sensation thresholds,
decreases sensation ratings, and increases compliance in response to balloon distension in
the colon; 2) pregabalin reduces colonic phasic and tonic motility in response to a
standardized meal; and 3) sensation ratings are lower with higher colonic compliance.
Phase:
Phase 4
Details
Lead Sponsor:
Mayo Clinic
Collaborators:
National Center for Research Resources (NCRR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)