Pregabalin Versus Gabapentin Opioid Sparing Effect in Discectomy
Status:
Enrolling by invitation
Trial end date:
2022-11-01
Target enrollment:
Participant gender:
Summary
Pregabalin and gabapentin are both GABA analogue and their mechanism of action is not fully
understood. Both drugs when given as a pre-emptive analgesia for spinal surgery were found to
reduce intra-and postoperative opioid requirements.
Preoperative intramuscular injection of morphine could reduce the patients' pain during the
percutaneous transformational endoscopic discectomy "PTED" surgery and improve the patients'
satisfaction without affecting the surgical outcome. The efficacy of adding pregabalin or
gabapentin to preoperative intramuscular morphine is not yet investigated.
The current study aims to compare the analgesic effect of both drugs when given
preoperatively with intramuscular morphine.