Pregabalin Effects on Hypotensive Anesthesia During Spine Surgery.

• Status: Completed
• Trial end date: 2019-04-30
• Target enrollment: 0
• Participant gender: All

Summary

Elective lumbar spine surgical procedures are commonly performed under controlled hypotension during general anesthesia. That is beneficial to limit the intraoperative blood loss and transfusions and improves surgical field. Deliberate hypotension could be achieved via various medications but mostly associated with significant side effects. Pregabalin effectively augmented hypotensive anesthesia. The hypothesis is that Pregabalin 150 mg single preoperative dose may augment intraoperative deliberate hypotension that will be reflected on blood loss and nitroglycerin consumption.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Anesthetics; Antihypertensive Agents; Pregabalin

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) score I-II

• admitted to undergo lumbar discectomy or spinal fixation surgery under general anesthesia

Exclusion Criteria:

• Patients on anti-hypertensive treatment, diuretics, corticosteroids, pregabalin, gabapentin, anticonvulsants, antipsychotics,

• alcohol addiction or drug abuse

• patients with history of allergy to any drug used in the study .

• pregnant or nursing women

• patients with peripheral neuropathy, endocrinal diseases, bleeding abnormality,

• cardiac, hepatic or renal impairment