Pregabalin, Celecoxib, Total Knee Arthroplasty and Intrathecal Morphine

• Status: Completed
• Trial end date: 2010-10-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate whether pregabalin and/or celecoxib could improve analgesic efficacy of intrathecal morphine for patients after total knee arthroplasty.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Chulalongkorn University
• Collaborators: Bhumibol Adulyadej Hospital; King Chulalongkorn Memorial Hospital
• Treatments: Anesthetics; Celecoxib; Morphine; Pregabalin

Criteria

Inclusion Criteria:

• Patients between 50-75 years of age

• Patients with an American Society of Anesthesiologists physical status of I to III

• Patients scheduled for primary TKA with a diagnosis of osteoarthritis under spinal anesthesia

Exclusion Criteria:.

• Patients had a known allergy to any of the medications being used

• a history of drug or alcohol abuse

• a history of taking chronic pain medications (ie, show-release preparations of opioids, given that morphine consumption was the primary outcome)

• a history of taking pregabalin or gabapentin / non-steroidal anti-inflammatory drugs / COX-2 inhibitors

• a psychiatric disorder

• a history of impaired renal function (Cr > 1.5 mg/dl), peptic ulcer, asthma, thrombotic cerebrocardiovascular diseases, uncontrolled hypertension

• a history of contraindication for spinal anesthesia

• a history of bleeding tendency

• pregnancy

• unable or unwilling to use patient - controlled analgesic (PCA)