Preemptive Oral Gabapentin 600 mg in Reducing Morphine Requirement After Non Obstetric Lower Abdominal Surgery

• Status: Completed
• Trial end date: 2020-02-29
• Target enrollment: 0
• Participant gender: All

Summary

This study aimed to get the information about the effectiveness of preemptive oral gabapentin 600 mg in reducing morphine requirement after non obstetric lower abdominal surgery

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indonesia University
• Treatments: Gabapentin

Criteria

Inclusion criteria:

• Male or female

• Age: 18-65 years old

• Weigh in range around 20% of the ideal body weight

• Physical status ASA I-II

• Scheduled for elective non-obstetric lower abdominal surgery with general anesthesia

• Duration of surgery less than 4 hours

• Patients who agreed to participate in this study and sign informed consent

Exclusion criteria:

• Patients who have history of allergy or hypersensitivity to gabapentin, paracetamol, morphine, or the other opioids

• Patients who consumed analgesia and NSAID less than 12 hours before surgery

• Patients who experienced physical trauma less than 4 days before surgery

• Patients who have contraindications to gabapentin, morphine, and paracetamol

• Patients who were treated with neuraxial block or peripheral nerve block before and during surgery

• Patients who have history of diabetes, severe live or renal disease

• Patients who were treated with antihypertension, sedatives, hypnotics, antidepressants, and the other drugs that have effects on nervous system

• Patients who have psychiatric disorders

• Patients who consumed gabapentin before perioperative period

• Pregnant or breastfeeding patients