Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
Laminoplasty and laminectomy have been used for decades for the treatment of intraspinal
space occupying lesions, spinal stenosis, disc herniation, injuries, etc. After these
procedures, patients often experience severe postoperative pain at the surgical site.
However, current methods of pain control are mostly insufficient. At present, several pain
controlling methods are available, to reduce postoperative pain after laminoplasty or
laminectomy. Methods for systemic administration include: oral analgesics, intermittent
intravenous, intramuscular injections, patient- controlled intravenous analgesia, etc.
However, the aforementioned methods may have a lot of side effects, and are usually used
after the occurrence of pain and the analgesic effects are sometimes inadequate. Topical
administration options use a lower dose of drugs and therefore have less systemic side
effects. Pre-emptive injection of local anesthetics can significantly reduce postoperative
pain during rest and movement, however, the analgesic effect is maintained for a relatively
short period of time. It is necessary to use more cases to explore the other compatibility of
drugs with longer duration of action and stronger analgesic effect. Betamethasone as the
stereoisomer of dexamethasone is a long-acting corticosteroid, which has long lasting
anti-inflammatory properties. Whether betamethasone combined with local anesthetic for
laminoplasty or laminectomy has better short-term and long-term effects than the local
anesthetic alone has not been reported yet. Therefore, a prospective, randomized, controlled,
blinded-endpoint study is needed to compare the postoperative analgesic efficacy of
preemptive wound infilteration of ropivacaine alone and betamethasone plus ropivacaine for
laminectomy or laminoplasty.