Preemptive Analgesia With Amitryptyline for Prevention of Pain in Women After Hysterectomy

• Status: Completed
• Trial end date: 2018-10-30
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine whether amitryptyline is effective in the prevention of pain in women after a total abdominal hysterectomy.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Campinas, Brazil
• Treatments: Amitriptyline; Amitriptyline, perphenazine drug combination

Criteria

Inclusion Criteria:

• Women scheduled for total abdominal hysterectomy for benign conditions (e.g. hemorrhagic and / or uterine fibroid disorder);

• Age between 18 and 60;

Exclusion Criteria:

• Endometriosis;

• Abnormal cervicovaginal smears;

• Uterine prolapse;

• Patients with a history of intolerance to opioids or narcotics;

• Patients with contraindications to the use of amitriptyline (e.g., ischemic heart disease, glaucoma)

• addicted to alcohol or drugs;

• Use of analgesics in the 24 hours prior to the possible administration of amitriptyline;

• Failure to provide informed consent;

• Different anesthesia from spinal anesthesia