Predictors of response to pharmacological treatment of major depressive disorder will be
investigated. One hundred and twenty patients will be included in a naturalistic clinical
trial. Psychopathology, personality traits, cognitive performance, brain structural changes
and genetic polymorphisms will be evaluated. Patients will be followed for 18 months with a
pharmacological treatment algorithm and will be evaluated monthly until 6th month and every 3
months, up to 18 months. Psychoeducation will be offered to patients who did not remit until
3 months of pharmacological tretment.
Details
Lead Sponsor:
University of Sao Paulo General Hospital
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo