Predictors of Cognitive Outcomes in Geriatric Depression

• Status: Recruiting
• Trial end date: 2026-06-30
• Target enrollment: 0
• Participant gender: All

Summary

This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging. Understanding how effects of stress in older depressed adults, as well as factors that might minimize those effects, lead to particular mood and cognitive outcomes will inform future development of novel prevention strategies.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: David Steffens
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Bupropion; Desvenlafaxine Succinate; Sertraline

Criteria

Inclusion Criteria:

• major depression, single episode or recurrent;

• ability to read and write English;

• Mini-Mental State Examination >25.

Exclusion Criteria:

• lifetime alcohol/drug dependence

• conditions associated with brain abnormalities such hydrocephalus, benign and cancerous brain tumors, epilepsy, Parkinson's disease, Huntington's chorea, dementia, demyelinating diseases, etc.

• untreated endocrine disorder other than diabetes mellitus

• established clinical diagnosis of dementia

• other primary psychiatric disorders, e.g., panic disorder, social phobia, obsessive- compulsive disorder, schizoaffective disorder, schizophrenia, bipolar disorder