Predicting Treatment Response in Patients With OCD
Status:
Recruiting
Trial end date:
2021-12-21
Target enrollment:
Participant gender:
Summary
This study consists of a naturalistic follow-up of subjects with Obsessive-Compulsive
Disorder (OCD) that have participated in a global study investigating brain signatures of OCD
funded by the National Institutes of Mental Health (RO1MH113250), with the following
participant sites: the US (Columbia University, PI: Helen Blair Simpson), Brazil (University
of Sao Paulo, PIs: Euripedes Miguel and Roseli G Shavitt), India (National Institutes of
Mental Health, PI: Janardhan Reddy), The Netherlands (VU Amsterdam Medical Center, PI: Odile
van den Heuvel), and South Africa (University of Cape Town, PI: Dan Stein; Stellenbosch
University, PI: Christine Lochner). In this cross-sectional study, two-hundred and fifty
unmedicated subjects with OCD (50 per site) will be assessed for clinical, neurocognitive and
neuroimaging data. After completion of this study, participants willing to receive
evidence-based treatments for OCD will be treated with the available resources in each site
and will be assessed for treatment response status periodically, with a final assessment
after 1 year of naturalistic follow-up. At this point, we will investigate baseline clinical,
neurocognitive and neuroimaging variables associated with the treatment response status.
Phase:
Phase 4
Details
Lead Sponsor:
University of Sao Paulo
Collaborators:
Columbia University National Institute of Mental Health and Neuro Sciences, India University of Stellenbosch VU University Medical Center