Precision Treatment With Angiotensin Converting Enzyme Inhibitor
Status:
Completed
Trial end date:
2021-08-02
Target enrollment:
Participant gender:
Summary
Angiotensin converting enzyme inhibitors (ACEI) are the first-line treatment for high blood
pressure and congestive heart failure, and have excellent effects in improving the prognosis
of cardiovascular diseases. However, ACEI is frequently discontinued due to its adverse
reaction. The adverse reaction to ACEI is not uncommon, especially in Asians. Discontinuation
of ACEI is known to increase the risk of poor prognosis of cardiovascular diseases.
Biomarkers for predicting adverse reaction to ACEI have not yet been developed. Recently,
genes related to adverse reaction to ACEI have been identified. This study is a randomized
prospective study, in which the experimental group decides whether to administer the drug
based on genetic information, and the control group decides whether to administer the drug
without the information. In the experimental group, participants who are predicted to have a
high risk of adverse reation to ACEI will receive angiotensin receptor blockers (ARB), and
those who are predicted to have a low risk of adverse reaction will receive ACEI. Control
group will receive ACEI. The frequency of adverse reaction will be investigated between
control and experimental groups. In the genotyping and control groups, at least 45 and 31
will be enrolled, respectively, and after drug administration, a phone follow-up will be
conducted at 3 weeks, followed by a visit at the 6th week, and the study will be terminated.