Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL
Status:
Unknown status
Trial end date:
2021-05-30
Target enrollment:
Participant gender:
Summary
Based on the pediatric-inspired, PEG-L-asparaginase-intensified and MRD-directed PDT-ALL-2016
protocol, this open-label, one-arm, multi-site trial PDT-ALL-LBL is aimed to evaluate the
safety and effect of oral histone deacetylase inhibitor chidamide for adult T-ALL/LBL.
Compared to PDT-ALL-2016 for B-ALL, HDACi chidamide will be administrated from induction
therapy to maintenance therapy, along with higher dose of consolidation regimen of
cytarabine, methotrexate, cyclophosphamide.