Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion

• Status: Completed
• Trial end date: 2010-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate brain injury when two different drugs (propofol and precedex) are used to sedate patients who need a neurologic exam.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Carmelo Graffagnino
• Collaborators: Hospira, Inc.; Hospira, now a wholly owned subsidiary of Pfizer
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• primary diagnosis of Traumatic Brain Injury (TBI), Subarachnoid Hemorrhage (SAH),Intracranial Hemorrhage (ICH), stroke

• Must require (be on) mechanical ventilation

• must require (have in place) intracranial pressure (ICP) monitoring

• must require (be receiving) continuous IV sedation

Exclusion Criteria:

• Bleeding diathesis

• Glasgow Coma Scale (GCS) < 5 with fixed pupils

• Pregnant

• elevated ICP that requires deep sedation

• pulmonary instability

• Hx of Ethanol(ETOH) abuse that requires current benzodiazepine treatment for delirium
• allergy to propofol or precedex

• status epilepticus

• current neuromuscular blockade