Pre Transplant Rapamycin Treatment in Islet Transplantation Alone
Status:
Completed
Trial end date:
2009-09-01
Target enrollment:
Participant gender:
Summary
Numerous changes to the original Edmonton protocol have been proposed in the attempt of
improving the still unsatisfactory long-term function of ITA. Rapamycin may blunt the early
inflammatory response to islet transplantation in the liver, thus favoring islet engraftment.
Aim of the investigators study was to evaluate the effect of a pre-transplant treatment with
rapamycin in patients with type 1 diabetes receiving islet transplant alone and
immunosuppression according to the Edmonton protocol.
Phase:
Phase 3
Details
Lead Sponsor:
IRCCS San Raffaele
Collaborators:
Juvenile Diabetes Research Foundation Ministry of Education, Universities and Research, Italy Telethon-JDRF Center for Beta cell replacement: clinical core.