Pre-Surgical Intervention for Targeted Therapies for Breast Cancer
Status:
Completed
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the feasibility of a short term administration of a
targeted therapy (i.e., anastrozole) in women with newly diagnosed early invasive or non
invasive breast cancer during the interval between their breast biopsy and surgery.
Anastrozole is a form of hormonal therapy which is part of the standard treatment for hormone
sensitive breast cancer in postmenopausal women. This clinical model is being used to
evaluate the biologic effects of this drug on a specific molecular pathway called the
PI3K/AKT signaling pathway.