Pravastatin, Idarubicin, and Cytarabine in Treating Patients With Acute Myeloid Leukemia
Status:
Completed
Trial end date:
2005-10-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as idarubicin and cytarabine, work in different
ways to stop the growth of cancer cells, either by killing the cells or by stopping them from
dividing. Pravastatin may help idarubicin and cytarabine work better by making cancer cells
more sensitive to the drugs. Giving pravastatin together with idarubicin and cytarabine may
kill more cancer cells.
PURPOSE: This phase I trial is studying the side effects and best dose of pravastatin when
given together with idarubicin and cytarabine in treating patients with acute myeloid
leukemia.