Prasugrel With Lower Dose - Loading Dose

• Status: Completed
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Although prasugrel, recently available thienopyridine derivative, exhibits rapid and potent platelet inhibition, concerns of low on-treatment platelet reactivity have been suggested especially in East Asian ethnicities. The investigators compared the effect of lower loading dose of prasugrel with conventional loading dose of clopidogrel and prasugrel.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Dong-A University
• Treatments: Clopidogrel; Prasugrel Hydrochloride; Ticlopidine

Criteria

Inclusion Criteria:

• Patients between 18 and 80 years

• Stable or unstable angina

• Planned to undergo elective coronary angiography

Exclusion Criteria:

• Previous history of transient ischemic attack or stroke

• Intracranial neoplasm

• Uncontrolled malignant disease

• History of antiplatelet or anticoagulation treatment within 1 month

• Contraindication to the study drug

• Bleeding diathesis

• Hemoglobin < 10 g/dl

• Platelet count < 100,000/mm3

• Significant renal insufficiency (glomerular filtration rate <60 mL/min/1.73 m2)

• Significant hepatic impairment (Serum liver enzyme or bilirubin > 3 times normal limit)

• Body weight < 50 kg