Overview

Povidone-Iodine Rinses as an Adjuvant Therapy Post-Operatively

Status:
Not yet recruiting
Trial end date:
2021-02-10
Target enrollment:
0
Participant gender:
All
Summary
Povidone Iodine solution is a nasal antiseptic. Its application has been shown to be clinically safe, tolerable and effective against bacteria and fungi associated with chronic rhinosinusitis. The purpose of this study is determining the effectiveness of PVP-I in comparison to a placebo for post-operative refractory CRS patients in a randomized controlled trial.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
St. Paul's Hospital, Canada
Treatments:
Cadexomer iodine
Iodine
Pharmaceutical Solutions
Povidone
Povidone-Iodine
Criteria
Inclusion Criteria:

- 19 years or older

- Undergoing FESS at St. Paul's Hospital or False Creek Surgical Centre

Exclusion Criteria:

- Patients with sinonasal tumors.

- Patients who previously used PVP-I rinses - Patients with autoimmune diseases
affecting the upper airway

- eg Systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis etc.

- Immuno-compromised patients, and patients with impairment in mucociliary function

- (e.g., cystic fibrosis, Kartagener syndrome)

- Hypersensitivity to iodine

- History of thyroid disorders including thyroid cancer, hyperthyroidism and
hypothyroidism

- Use of medications for thyroid disorders including thyroxine and carbimazole

- Pregnancy

- Patients unable to speak English.